Resources

CPPF services include:

  1. Pharmacokinetics, including assay development, validation, identification and/or quantitation of drugs, metabolites, metabolizing enzymes, and other endogenous products in biological matrices, and PK analysis/modeling. View the list of PK assays offered by the CPPF.
  2. Pharmacodynamics, including assay development, validation, and sample analysis.
  3. Consultation, aiding investigators in the experimental design of studies involving analytical chemical, PK, or PD efforts, and liaising with existing facilities and investigators to minimize financial costs and maximize scientific revenue for each project.
  4. Integration, performing PK/PD correlations and correlating PK or PD metrics with clinical outcomes.

Services are evaluated on a regular basis to assess levels of scientific demand, potential benefits of research, and financial feasibility. The facility encourages suggestions and requests for new assays or instrumentation from investigators that require additional support for their research activities. The CPPF attempts to maintain maximum flexibility, and is eager to work with individuals on special project needs that are not necessarily regular activities within the facility. The CPPF strives to support and enhance the research environment; every effort is made to acquire new instrumentation, software, or capabilities as the field of analytical chemistry and pharmacokinetics advances in technique and concept.

Learn more about projects supported by the CPPF.

Equipment

Equipment Name Description
Agilent Technologies 1260 Infinity II HPLC Agilent technologies 1260 Infinity II Series HPLC with variable wavelength detector, Fluorescence detector, and Diode array detector
LI-COR Biosciences Odyssey CLx The LI-COR Odyssey CLx is a dual-wavelength near-infrared fluorescence imaging system designed for quantitative Western blotting and multiplex protein analysis.
SCIEX 4000 LC-MS/MS system The SCIEX 4000 LC-MS/MS system is a legacy, industry-workhorse tandem mass spectrometer known for high-performance quantitation and reliability.
SCIEX 4000Q LC-MS/MS system The SCIEX 4000 LC-MS/MS system is a legacy, highly reliable triple quadrupole and hybrid 4000 QTRAP LC-MS/MS System platform widely used for quantitative and qualitative analysis.
SCIEX 4500 LC-MS/MS system The SCIEX 4500 LC-MS/MS system is a rugged, high-performance benchtop mass spectrometer built for reliable, high-throughput quantitation.
SCIEX 6500+ LC-MS/MS system The SCIEX 6500+ LC-MS/MS system is a high-performance tandem mass spectrometer designed for ultra-sensitive quantification, low-abundance analyte detection, and complex matrix analysis.
Tecan Group Lrd. Spark The Spark Multimode Microplate Reader by Tecan Group is a modular, high-performance detection system designed for life science research and drug discovery.