A skilled research technician focused on the fidelity and quality of data, and with over 15 years of Flow Cytometry experience, Joshua Michel ensures the Rangos Flow Core produces high quality data and sorted specimens. He has first hand experience in coordination of sample collection, preparation, and staining of mouse and human samples for Flow Cytometry and Luminex assays. Blood and tissue protocols are numerous and ponderous, and he is always willing to discuss the details. Designing or changing multicolor Flow Cytometry staining panels can be difficult and may require craftiness and experience. He enjoys the challenge of new problems and responds with readiness to the level of detail required. Whether it be fluorescently labelled antibody staining, nuclear staining, metabolic stains, or cell sorting, he is ready to assist in the design, implementation, and measurement of analytes and antigens in various specimen types. His interests include data analysis and information science, and he is able to utilize a variety of platforms to assist in the production of diagrams and presentations of data.
- BA, Physics, University of Minnesota, 2011
Education & Training
- Harry and Viola St. Cyr Scholarship, University of Minnesota, 1998
Casillo SM, Gatesman TA, Chilukuri A, Varadharajan S, Johnson BJ, David Premkumar DR, Jane EP, Plute TJ, Koncar RF, Stanton AJ, Biagi-Junior CAO, Barber CS, Halbert ME, Golbourn BJ, Halligan K, Cruz AF, Mansi NM, Cheney A, Mullett SJ, Land CV, Perez JL, Myers MI, Agrawal N, Michel JJ, Chang YF, Vaske OM, MichaelRaj A, Lieberman FS, Felker J, Shiva S, Bertrand KC, Amankulor N, Hadjipanayis CG, Abdullah KG, Zinn PO, Friedlander RM, Abel TJ, Nazarian J, Venneti S, Filbin MG, Gelhaus SL, Mack SC, Pollack IF, Agnihotri S. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell Rep. 2024 Jan 23;43(1):113557. doi: 10.1016/j.celrep.2023.113557. Epub 2023 Dec 18. PMID: 38113141.
Shang P, Simpson JD, Taylor GM, Sutherland DM, Welsh OL, Aravamudhan P, Natividade RDS, Schwab K, Michel JJ, Poholek AC, Wu Y, Rajasundaram D, Koehler M, Alsteens D, Dermody TS. Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nat Commun. 2023 May 5;14(1):2615. doi: 10.1038/s41467-023-38327-6. PMID: 37147336; PMCID: PMC10163058.
Vallejo AN, Mroczkowski HJ, Michel JJ, Woolford M, Blair HC, Griffin P, McCracken E, Mihalik SJ, Reyes-Mugica M, Vockley J. Pervasive inflammatory activation in patients with deficiency in very-long-chain acyl-coA dehydrogenase (VLCADD). Clin Transl Immunology. 2021 Jun 27;10(6):e1304. doi: 10.1002/cti2.1304. PMID: 34194748; PMCID: PMC8236555.
Chen, Apeng, et al. "Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma." The Journal of clinical investigation 131.16 (2021): e147552.
Griffin P, Michel JJ, DeVallejo AN. “Diversity of CD28 null T Cells in the Elderly: A Glimpse in a Biological Adaptation of Aging.” Handbook of Immunosenescence. November 2018. DOI:10.1007/978-3-319-64597-1_87-1
Ferguson ID, Griffin P, Michel JJ, Yano H, Gaffen SL, Mueller RG, Dvergsten JA, Piganelli JD,Rosenkranz ME, Kietz DA and Vallejo AN. (2018.) “T Cell Receptor-Independent, CD31/IL-17A-DrivenInflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.” Front. Immunol. 9:1802. doi: 10.3389/fimmu.2018.01802.
Michel JJ, Griffin P and Vallejo Abbe N (2016). “Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging.” Front. Immunol. 7:530. doi: 10.3389/fimmu.2016.00530.
Meghan E Fitzpatrick, Vikas Singh, Marnie Bertolet, Lorrie Lucht, Cathy Kessinger, Joshua Michel, Alison Logar, Renee Weinman, Deborah McMahon, Karen A Norris, Abbe N Vallejo, Alison Morris. “Relationships of pulmonary function, inflammation, and T-cell activation and senescence in an HIV-infected cohort.” AIDS. 2014 Nov 13;28(17):2505-15. doi: 10.1097/QAD.0000000000000471.
Dvergsten JA, Mueller RG, Griffin P, Abedin S, Pishko A, Michel JJ, Rosenkranz ME, Reed AM, Kietz DA and Vallejo AN. “Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.” Arthritis Rheum. 2013 Aug;65(8):2201-10. doi: 10.1002/art.38015.
Griffin P, Michel JJ, Huysman K, Logar AJ, Vallejo AN. Integration of immunity with physical and cognitive function in definitions of successful aging. Aging Dis. 2012 Feb;3(1):34-50. Epub 2012 Feb 27.